Intradermal grass pollen immunotherapy increases T_H2 and IgE responses and worsens respiratory allergic symptoms.

ABSTRACT:

Background

Repeated low-dose grass pollen intradermal allergen injection suppresses allergen-induced cutaneous late-phase responses comparably with conventional subcutaneous and sublingual immunotherapy.

Objective

We sought to evaluate the efficacy and safety of grass pollen intradermal immunotherapy in the treatment of allergic rhinitis.

Methods

We randomly assigned 93 adults with grass pollen-induced allergic rhinitis to receive 7 preseasonal intradermal allergen injections (containing 7 ng of Phl p 5 major allergen) or a histamine control. The primary end point was daily combined symptom-medication scores during the 2013 pollen season (area under the curve). Analysis was by intention to treat. Skin biopsy specimens were collected after intradermal allergen challeng

SUBMITTER: Slovick A 

PROVIDER: S-EPMC5457129 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature