Maternal and Fetal Outcomes of Anticoagulation in Pregnant Women With Mechanical Heart Valves.

ABSTRACT:

Background

Anticoagulation for mechanical heart valves during pregnancy is essential to prevent thromboembolic events. Each regimen has drawbacks with regard to maternal or fetal risk.

Objectives

This meta-analysis sought to estimate and compare the risk of adverse maternal and fetal outcomes in pregnant women with mechanical heart valves who received different methods of anticoagulation.

Methods

Studies were identified using a Medline search including all publications up to June 5, 2016. Study inclusion required reporting of maternal death, thromboembolism, and valve failure, and/or fetal spontaneous abortion, death, and congenital defects in pregnant women treated with any of the following: 1) a vitamin K antagonist (VKA) throughout pregnancy; 2) low-molecular-weigh

SUBMITTER: Steinberg ZL 

PROVIDER: S-EPMC5457289 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature