Longitudinal Changes in Volumetric Breast Density with Tamoxifen and Aromatase Inhibitors.

ABSTRACT: Background: Reductions in breast density with tamoxifen and aromatase inhibitors may be an intermediate marker of treatment response. We compare changes in volumetric breast density among breast cancer cases using tamoxifen or aromatase inhibitors (AI) to untreated women without breast cancer.Methods: Breast cancer cases with a digital mammogram prior to diagnosis and after initiation of tamoxifen (n = 366) or AI (n = 403) and a sample of controls (n = 2170) were identified from the Mayo Clinic Mammography Practice and San Francisco Mammography Registry. Volumetric percent density (VPD) and dense breast volume (DV) were measured using Volpara (Matakina Technology) and Quantra (Hologic) software. Linear regression estimated the effect of treatment on annua

SUBMITTER: Engmann NJ 

PROVIDER: S-EPMC5457346 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature