Potassium channel gene associations with joint processing speed and white matter impairments in schizophrenia.

ABSTRACT: Patients with schizophrenia show decreased processing speed on neuropsychological testing and decreased white matter integrity as measured by diffusion tensor imaging, two traits shown to be both heritable and genetically associated indicating that there may be genes that influence both traits as well as schizophrenia disease risk. The potassium channel gene family is a reasonable candidate to harbor such a gene given the prominent role potassium channels play in the central nervous system in signal transduction, particularly in myelinated axons. We genotyped members of the large potassium channel gene family focusing on putatively functional single nucleotide polymorphisms (SNPs) in a population of 363 controls, 194 patients with schizophrenia spectrum disorder (SSD) and 28 patients with

SUBMITTER: Bruce HA 

PROVIDER: S-EPMC5457349 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature