Segmental Duplication of Chromosome 11 and its Implications for Cell Division and Genome-wide Expression in Rice.

ABSTRACT: Segmental duplication is a major structural variation that occurs in chromosomes. Duplication leads to the production of gene copies with increased numbers of related repeat segments, causing the global genome to be in a state of imbalance. In addition, if the added segment contains a centromeric specific DNA, the duplicated chromosome will have structural multiple centromeres. We identified a segmental duplication containing structurally tricentric regions derived from the short arm of chromosome 11 (11L∙ + 11L∙ + 11S∙11S∙11S∙11S, "∙" represents the centromeric DNA repeat loci), and analyzed its implications for cell division and genome-wide expression. In the variant, only the middle centromere of 11S∙11S∙11S∙11S is functionally active. As a result, the structurally tricentric chromosome

SUBMITTER: Zhang R 

PROVIDER: S-EPMC5457480 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature