Ontology highlight
ABSTRACT:
SUBMITTER: Loke J
PROVIDER: S-EPMC5457485 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Cell reports 20170501 8
Acute myeloid leukemia (AML) is a heterogeneous disease caused by mutations in transcriptional regulator genes, but how different mutant regulators shape the chromatin landscape is unclear. Here, we compared the transcriptional networks of two types of AML with chromosomal translocations of the RUNX1 locus that fuse the RUNX1 DNA-binding domain to different regulators, the t(8;21) expressing RUNX1-ETO and the t(3;21) expressing RUNX1-EVI1. Despite containing the same DNA-binding domain, the two ...[more]