ATF2, a paradigm of the multifaceted regulation of transcription factors in biology and disease.

ABSTRACT: Stringent transcriptional regulation is crucial for normal cellular biology and organismal development. Perturbations in the proper regulation of transcription factors can result in numerous pathologies, including cancer. Thus, understanding how transcription factors are regulated and how they are dysregulated in disease states is key to the therapeutic targeting of these factors and/or the pathways that they regulate. Activating transcription factor 2 (ATF2) has been studied in a number of developmental and pathological conditions. Recent findings have shed light on the transcriptional, post-transcriptional, and post-translational regulatory mechanisms that influence ATF2 function, and thus, the transcriptional programs coordinated by ATF2. Given our current knowledge of its multiple leve

SUBMITTER: Watson G 

PROVIDER: S-EPMC5457671 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature