Autologous transplantation of cytokine-induced killer cells as an adjuvant therapy for hepatocellular carcinoma in Asia: an update meta-analysis and systematic review.

ABSTRACT:

Background

High recurrence rate after curative treatment is the major problem for hepatocellular carcinoma (HCC). Cytokine-induced killer cells (CIKs) therapy was extensively studied among HCC patients. However, the value of CIKs therapy was controversial. A meta-analysis was performed to investigate the efficacy of adjuvant CIKs after invasive treatments among HCC patients.

Methods

We searched online for literatures studying sequential CIKs therapy for HCC patients. Recurrence-free survival (RFS), progress-free survival (PFS) and overall survival (OS) were set as the main endpoints. Both overall and subgroup analysis were accomplished.

Results

A total of 12 clinical trials with 1,387 patients were included. The pooled analysis showed a significant improvement of RFS,

SUBMITTER: Cai XR 

PROVIDER: S-EPMC5458210 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature