Early Emergence of CD19-Negative Human Antibody-Secreting Cells at the Plasmablast to Plasma Cell Transition.

ABSTRACT: Long-lived human plasma cells (PCs) play central roles in immunity and autoimmunity and are enriched among the subpopulation of CD19^neg human PCs. However, whether human CD19^neg PCs are necessarily aged cells that have gradually lost CD19 expression is not known. Assessing peripheral blood samples at steady-state and during the acute response to influenza vaccination in healthy donors, we identify the presence of phenotypic CD19^neg plasmablasts, the proliferative precursor state to mature PCs, and demonstrate by ELISPOT that these are Ab-secreting cells (ASCs). During the acute response to influenza vaccination, CD19^pos, CD19^low, and CD19^neg ASCs secrete vaccine-specific Abs and show linked IGHV repertoires. To addres

SUBMITTER: Arumugakani G 

PROVIDER: S-EPMC5458329 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature