Hormone-dependent control of developmental timing through regulation of chromatin accessibility.

ABSTRACT: Specification of tissue identity during development requires precise coordination of gene expression in both space and time. Spatially, master regulatory transcription factors are required to control tissue-specific gene expression programs. However, the mechanisms controlling how tissue-specific gene expression changes over time are less well understood. Here, we show that hormone-induced transcription factors control temporal gene expression by regulating the accessibility of DNA regulatory elements. Using the Drosophila wing, we demonstrate that temporal changes in gene expression are accompanied by genome-wide changes in chromatin accessibility at temporal-specific enhancers. We also uncover a temporal cascade of transcription factors following a pulse of the steroid hormone ecd

SUBMITTER: Uyehara CM 

PROVIDER: S-EPMC5458754 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature