Parental Age and Offspring Psychopathology in the Philadelphia Neurodevelopmental Cohort.

ABSTRACT:

Objective

Increasing evidence implicates advanced paternal age at offspring birth in neuropsychiatric disorders. Advanced maternal age has also been associated with schizophrenia and other neurodevelopmental disorders, whereas younger maternal age has been linked with behavioral disorders. Few studies have considered the specificity of the associations with respect to comorbidity. In addition, most prior studies have been conducted in clinical samples or registries that may reflect more severe forms of psychopathology. The aim of this research is to examine the independent and joint associations of maternal and paternal age with specific subtypes of psychopathology in offspring in a pediatric sample of adolescents with emergent psychiatric syndromes.

Method

A total of 8,725

SUBMITTER: Merikangas AK 

PROVIDER: S-EPMC5458772 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature