Ontology highlight
ABSTRACT:
SUBMITTER: Boza V
PROVIDER: S-EPMC5459436 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Boža Vladimír V Brejová Broňa B Vinař Tomáš T
PloS one 20170605 6
The MinION device by Oxford Nanopore produces very long reads (reads over 100 kBp were reported); however it suffers from high sequencing error rate. We present an open-source DNA base caller based on deep recurrent neural networks and show that the accuracy of base calling is much dependent on the underlying software and can be improved by considering modern machine learning methods. By employing carefully crafted recurrent neural networks, our tool significantly improves base calling accuracy ...[more]