The role of neuropeptide-Y in nandrolone decanoate-induced attenuation of antidepressant effect of exercise.

ABSTRACT: Since the increased prevalence of anabolic androgenic steroids abuse in last few decades is usually accompanied by various exercise protocols, the scope of our study was to evaluate the effects of chronic nandrolone decanoate administration in supraphysiological dose and a prolonged swimming protocol (alone and simultaneously with nandrolone decanoate) on depressive state in male rats. Simultaneously, we investigated the possible alterations in neuropeptide Y (NPY) content in blood and the hippocampus, in order to determine the role of NPY in the modulation of depressive-like behavior.Exercise induced antidepressant effects in tail suspension test (decrease of the total duration of immobility), as well as significant increase in the number of hippocampal NPY-interneurons in CA1 region. Chr

SUBMITTER: Joksimovic J 

PROVIDER: S-EPMC5459494 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature