MicroRNA profiling in the dentate gyrus in epileptic rats: The role of miR-187-3p.

ABSTRACT: This study aimed to explore the role of aberrant miRNA expression in epilepsy and to identify more potential genes associated with epileptogenesis.The miRNA expression profile of GSE49850, which included 20 samples from the rat epileptic dentate gyrus at 7, 14, 30, and 90 days after electrical stimulation and 20 additional samples from sham time-matched controls, was downloaded from the Gene Expression Omnibus database. The significantly differentially expressed miRNAs were identified in stimulated samples at each time point compared to time-matched controls, respectively. The target genes of consistently differentially expressed miRNAs were screened from miRDB and microRNA.org databases, followed by Gene Ontology (GO) and pathway enrichment analysis and regulatory network construction. Th

SUBMITTER: Zhang S 

PROVIDER: S-EPMC5459693 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature