The association of six single nucleotide polymorphisms and their haplotypes in CDH13 with T2DM in a Han Chinese population.

ABSTRACT: T-cadherin (CDH13) is an adiponectin receptor. Genome-wide association studies have identified the CDH13 gene as one of the most important candidate genes in influencing plasma adiponectin levels. Several studies recently reported single-nucleotide polymorphisms (SNPs) in CDH13 gene were associated with T2DM. The purpose of this study was to investigate the association between T2DM and 6 SNPs (rs11646213, rs12596316, rs3865188, rs12444338, rs12051272, and rs7195409) in the CDH13 gene in a Han Chinese population. A total of 674 subjects with T2DM and 588 subjects without T2DM were genotyped using the TaqMan method. Our data showed that there was an association between the SNP-rs12596316 genotype and T2DM (P < .05). Moreover, an overdominant model of inheritance showed that being an rs125963

SUBMITTER: Li Y 

PROVIDER: S-EPMC5459737 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature