Immune signatures of pathogenesis in the peritoneal compartment during early infection of sheep with Fasciola hepatica.

ABSTRACT: Immune signatures of sheep acutely-infected with Fasciola hepatica, an important pathogen of livestock and humans were analysed within the peritoneal compartment to investigate early infection. Within the peritoneum, F. hepatica antibodies coincided with an intense innate and adaptive cellular immune response, with infiltrating leukocytes and a marked eosinophilia (49%). However, while cytokine qPCR analysis revealed IL-10, IL-12, IL-13, IL-23 and TGFβ were elevated, these were not statistically different at 18 days post-infection compared to uninfected animals indicating that the immune response is muted and not yet skewed to a Th2 type response that is associated with chronic disease. Proteomic analysis of the peritoneal fluid identified infection-related proteins, including several stru

SUBMITTER: Ruiz-Campillo MT 

PROVIDER: S-EPMC5459796 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature