Radiologic features of precancerous areas of the lungs in chronic obstructive pulmonary disease.

ABSTRACT:

Background

Only a few studies have evaluated the radiologic features of pre-existing structural abnormalities where lung cancer may develop. This study aimed to analyze the computed tomography (CT) images of lung areas where new cancer developed in chronic obstructive pulmonary disease (COPD) patients.

Patients and methods

We conducted a multicenter, longitudinal cohort study, called the Keio COPD Comorbidity Research, to assess the incidence of lung cancer. Emphysema and interstitial abnormalities were evaluated in 240 COPD patients who had baseline CT scans applicable for further digital analyses. For patients who developed lung cancer during the 3-year follow-up period, the local spherical lung density of the precancerous area was individually quantified.

Results

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SUBMITTER: Chubachi S 

PROVIDER: S-EPMC5459962 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature