Gene expression patterns associated with blood-feeding in the malaria mosquito Anopheles gambiae.

ABSTRACT:

Background

Blood feeding, or hematophagy, is a behavior exhibited by female mosquitoes required both for reproduction and for transmission of pathogens. We determined the expression patterns of 3,068 ESTs, representing ~2,000 unique gene transcripts using cDNA microarrays in adult female Anopheles gambiae at selected times during the first two days following blood ingestion, at 5 and 30 min during a 40 minute blood meal and at 0, 1, 3, 5, 12, 16, 24 and 48 hours after completion of the blood meal and compared their expression to transcript levels in mosquitoes with access only to a sugar solution.

Results

In blood-fed mosquitoes, 413 unique transcripts, approximately 25% of the total, were expressed at least two-fold above or below their levels in the sugar-fed mosquitoes, a

SUBMITTER: Dana AN 

PROVIDER: S-EPMC546002 | biostudies-literature | 2005 Jan

REPOSITORIES: biostudies-literature