Inner centromere localization of the CPC maintains centromere cohesion and allows mitotic checkpoint silencing.

ABSTRACT: Faithful chromosome segregation during mitosis requires that the kinetochores of all sister chromatids become stably connected to microtubules derived from opposite spindle poles. How stable chromosome bi-orientation is accomplished and coordinated with anaphase onset remains incompletely understood. Here we show that stable chromosome bi-orientation requires inner centromere localization of the non-enzymatic subunits of the chromosomal passenger complex (CPC) to maintain centromeric cohesion. Precise inner centromere localization of the CPC appears less relevant for Aurora B-dependent resolution of erroneous kinetochore-microtubule (KT-MT) attachments and for the stabilization of bi-oriented KT-MT attachments once sister chromatid cohesion is preserved via knock-down of WAPL. However, Aur

SUBMITTER: Hengeveld RCC 

PROVIDER: S-EPMC5460030 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature