'Mom-I don't want to hear it': Brain response to maternal praise and criticism in adolescents with major depressive disorder.

ABSTRACT: Recent research has implicated altered neural response to interpersonal feedback as an important factor in adolescent depression, with existing studies focusing on responses to feedback from virtual peers. We investigated whether depressed adolescents differed from healthy youth in neural response to social evaluative feedback from mothers. During neuroimaging, twenty adolescents in a current episode of major depressive disorder (MDD) and 28 healthy controls listened to previously recorded audio clips of their own mothers' praise, criticism and neutral comments. Whole-brain voxelwise analyses revealed that MDD youth, unlike controls, exhibited increased neural response to critical relative to neutral clips in the parahippocampal gyrus, an area involved in episodic memory encoding and retri

SUBMITTER: Silk JS 

PROVIDER: S-EPMC5460041 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature