Reconstitution of adaptive immunity after umbilical cord blood transplantation: impact on infectious complications.

ABSTRACT: In comparison with allogeneic stem cell transplantation (alloHSCT) with other stem cell sources, umbilical cord blood transplantation (UCBT) was traditionally associated with increased risk of infections, particularly during the first 3 months after transplantation. Longitudinal studies of immune monitoring reported peculiar patterns of T- and B-cell recovery in the peripheral blood of UCB recipients during the first months post-transplantation. Overall, current data suggest delayed reconstitution of naive and memory CD4⁺ and CD8⁺ T-cell pools after UCBT. This is particularly true for adult recipients and for patients who received in vivo T-cell depleting approaches before the transplantation. Such delayed T-cell recovery may increase susceptibility of UCB reci

SUBMITTER: Servais S 

PROVIDER: S-EPMC5460101 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature