An individual-based model for collective cancer cell migration explains speed dynamics and phenotype variability in response to growth factors.

ABSTRACT: Collective cell migration is a common phenotype in epithelial cancers, which is associated with tumor cell metastasis and poor patient survival. However, the interplay between physiologically relevant pro-migratory stimuli and the underlying mechanical cell-cell interactions are poorly understood. We investigated the migratory behavior of different collectively migrating non-small cell lung cancer cell lines in response to motogenic growth factors (e.g. epidermal growth factor) or clinically relevant small compound inhibitors. Depending on the treatment, we observed distinct behaviors in a classical lateral migration assay involving traveling fronts, finger-shapes or the development of cellular bridges. Particle image velocimetry analysis revealed characteristic speed dynamics (evolution o

SUBMITTER: Stichel D 

PROVIDER: S-EPMC5460121 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature