Investigation of simulated microgravity effects on Streptococcus mutans physiology and global gene expression.

ABSTRACT: Astronauts have been previously shown to exhibit decreased salivary lysozyme and increased dental calculus and gingival inflammation in response to space flight, host factors that could contribute to oral diseases such as caries and periodontitis. However, the specific physiological response of caries-causing bacteria such as Streptococcus mutans to space flight and/or ground-based simulated microgravity has not been extensively investigated. In this study, high aspect ratio vessel S. mutans simulated microgravity and normal gravity cultures were assessed for changes in metabolite and transcriptome profiles, H₂O₂ resistance, and competence in sucrose-containing biofilm media. Stationary phase S. mutans simulated microgravity cultures displayed inc

SUBMITTER: Orsini SS 

PROVIDER: S-EPMC5460135 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature