Neighbours of cancer-related proteins have key influence on pathogenesis and could increase the drug target space for anticancer therapies.

ABSTRACT: Even targeted chemotherapies against solid cancers show a moderate success increasing the need to novel targeting strategies. To address this problem, we designed a systems-level approach investigating the neighbourhood of mutated or differentially expressed cancer-related proteins in four major solid cancers (colon, breast, liver and lung). Using signalling and protein-protein interaction network resources integrated with mutational and expression datasets, we analysed the properties of the direct and indirect interactors (first and second neighbours) of cancer-related proteins, not found previously related to the given cancer type. We found that first neighbours have at least as high degree, betweenness centrality and clustering coefficient as cancer-related proteins themselves, indicati

SUBMITTER: Modos D 

PROVIDER: S-EPMC5460138 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature