Structural Modeling of Chromatin Integrates Genome Features and Reveals Chromosome Folding Principle.

ABSTRACT: How chromosomes fold into 3D structures and how genome functions are affected or even controlled by their spatial organization remain challenging questions. Hi-C experiment has provided important structural insights for chromosome, and Hi-C data are used here to construct the 3D chromatin structure which are characterized by two spatially segregated chromatin compartments A and B. By mapping a plethora of genome features onto the constructed 3D chromatin model, we show vividly the close connection between genome properties and the spatial organization of chromatin. We are able to dissect the whole chromatin into two types of chromatin domains which have clearly different Hi-C contact patterns as well as different sizes of chromatin loops. The two chromatin types can be respectively regarde

SUBMITTER: Xie WJ 

PROVIDER: S-EPMC5460185 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature