Conserved and species-specific molecular denominators in mammalian skeletal muscle aging.

ABSTRACT: Aging is a complex phenomenon involving functional decline in multiple physiological systems. We undertook a comparative analysis of skeletal muscle from four different species, i.e. mice, rats, rhesus monkeys, and humans, at three different representative stages during their lifespan (young, middle, and old) to identify pathways that modulate function and healthspan. Gene expression profiling and computational analysis revealed that pathway complexity increases from mice to humans, and as mammals age, there is predominantly an upregulation of pathways in all species. Two downregulated pathways, the electron transport chain and oxidative phosphorylation, were common among all four species in response to aging. Quantitative PCR, biochemical analysis, mitochondrial DNA measurements, and elec

SUBMITTER: Mercken EM 

PROVIDER: S-EPMC5460213 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature