Human uterine lymphocytes acquire a more experienced and tolerogenic phenotype during pregnancy.

ABSTRACT: Pregnancy requires a delicate immune balance that nurtures the allogeneic fetus, while maintaining reactivity against pathogens. Despite increasing knowledge, data is lacking on the transition of pre-pregnancy endometrial lymphocytes to a pregnancy state. Here, we immunophenotyped lymphocytes from endometrium (MMC), term decidua parietalis (DPMC), and PBMC for direct comparison. We found that the immune cell composition of MMC and DPMC clearly differ from each other, with less NK-cells, and more NKT-cells and T-cells in DPMC. An increased percentage of central memory and effector memory T-cells, and less naive T-cells in DPMC indicates that decidual T-cells are more experienced than endometrial T-cells. The increased percentage of CD4⁺CD25^highCD127^- Treg in

SUBMITTER: Feyaerts D 

PROVIDER: S-EPMC5460245 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature