Effect sizes in ongoing randomized controlled critical care trials.

ABSTRACT:

Background

An important limitation of many critical care trial designs is that they hypothesize large, and potentially implausible, reductions in mortality. Interpretation of trial results could be improved by systematic assessment of the plausibility of trial hypotheses; however, such assessment has not been attempted in the field of critical care medicine. The purpose of this study was to determine clinicians' views about prior probabilities and plausible effect sizes for ongoing critical care trials where the primary endpoint is landmark mortality.

Methods

We conducted a systematic review of clinical trial registries in September 2015 to identify ongoing critical care medicine trials where landmark mortality was the primary outcome, followed by a clinician survey to obtai

SUBMITTER: Ridgeon EE 

PROVIDER: S-EPMC5460326 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature