Comparative physical genome mapping of malaria vectors Anopheles sinensis and Anopheles gambiae.

ABSTRACT:

Background

Anopheles sinensis is a dominant natural vector of Plasmodium vivax in China, Taiwan, Japan, and Korea. Recent genome sequencing of An. sinensis provides important insights into the genomic basis of vectorial capacity. However, the lack of a physical genome map with chromosome assignment and orientation of sequencing scaffolds hinders comparative analyses with other genomes to infer evolutionary changes relevant to the vector capacity.

Results

Here, a physical genome map for An. sinensis was constructed by assigning 52 scaffolds onto the chromosomes using fluorescence in situ hybridization (FISH). This chromosome-based genome assembly composes approximately 36% of the total An. sinensis genome. Comparisons of 3955 orthologous genes between An. sinensis and Anophel

SUBMITTER: Wei Y 

PROVIDER: S-EPMC5460330 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature