Building a semantic web-based metadata repository for facilitating detailed clinical modeling in cancer genome studies.

ABSTRACT:

Background

Detailed Clinical Models (DCMs) have been regarded as the basis for retaining computable meaning when data are exchanged between heterogeneous computer systems. To better support clinical cancer data capturing and reporting, there is an emerging need to develop informatics solutions for standards-based clinical models in cancer study domains. The objective of the study is to develop and evaluate a cancer genome study metadata management system that serves as a key infrastructure in supporting clinical information modeling in cancer genome study domains.

Methods

We leveraged a Semantic Web-based metadata repository enhanced with both ISO11179 metadata standard and Clinical Information Modeling Initiative (CIMI) Reference Model. We used the common data elements (CDE

SUBMITTER: Sharma DK 

PROVIDER: S-EPMC5460361 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature