Risk factors for Clostridium difficile infections - an overview of the evidence base and challenges in data synthesis.

ABSTRACT:

Background

Recognition of a broad spectrum of disease and development of Clostridium difficile infection (CDI) and recurrent CDI (rCDI) in populations previously considered to be at low risk has renewed attention on differences in the risk profile of patients. In the absence of primary prevention for CDI and limited treatment options, it is important to achieve a deep understanding of the multiple factors that influence the risk of developing CDI and rCDI.

Methods

We conducted a review of systematic reviews and meta-analyses on risk factors for CDI and rCDI published between 1990 and October 2016.

Results

22 systematic reviews assessing risk factors for CDI (n = 19) and rCDI (n = 6) were included. Meta-analyses were conducted in 17 of the systematic reviews. Ov

SUBMITTER: Eze P 

PROVIDER: S-EPMC5460399 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature