Molecular signatures of neutrophil extracellular traps in human visceral leishmaniasis.

ABSTRACT:

Background

Infections with parasites of the Leishmania donovani complex result in clinical outcomes that range from asymptomatic infection to severe and fatal visceral leishmaniasis (VL). Neutrophils are major players of the immune response against Leishmania, but their contribution to distinct states of infection is unknown. Gene expression data suggest the activation of the NETosis pathway during human visceral leishmaniasis. Thus, we conducted an exploratory study to evaluate NET-related molecules in retrospective sera from VL patients, asymptomatic individuals and uninfected endemic controls.

Results

We demonstrate that VL patients and asymptomatic individuals exhibit differential regulation of molecules associated with neutrophil extracellular traps (NET). These differe

SUBMITTER: Gardinassi LG 

PROVIDER: S-EPMC5460406 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature