Gene expression and adaptive noncoding changes during human evolution.

ABSTRACT:

Background

Despite evidence for adaptive changes in both gene expression and non-protein-coding, putatively regulatory regions of the genome during human evolution, the relationship between gene expression and adaptive changes in cis-regulatory regions remains unclear.

Results

Here we present new measurements of gene expression in five tissues of humans and chimpanzees, and use them to assess this relationship. We then compare our results with previous studies of adaptive noncoding changes, analyzing correlations at the level of gene ontology groups, in order to gain statistical power to detect correlations.

Conclusions

Consistent with previous studies, we find little correlation between gene expression and adaptive noncoding changes at the level of individual genes;

SUBMITTER: Babbitt CC 

PROVIDER: S-EPMC5460488 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature