CMOST: an open-source framework for the microsimulation of colorectal cancer screening strategies.

ABSTRACT:

Background

Colorectal cancer (CRC) is a leading cause of cancer-related mortality. CRC incidence and mortality can be reduced by several screening strategies, including colonoscopy, but randomized CRC prevention trials face significant obstacles such as the need for large study populations with long follow-up. Therefore, CRC screening strategies will likely be designed and optimized based on computer simulations. Several computational microsimulation tools have been reported for estimating efficiency and cost-effectiveness of CRC prevention. However, none of these tools is publicly available. There is a need for an open source framework to answer practical questions including testing of new screening interventions and adapting findings to local conditions.

Methods

We develop

SUBMITTER: Prakash MK 

PROVIDER: S-EPMC5460500 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature