Systematic review with meta-analysis: the efficacy and safety of stem cell therapy for Crohn's disease.

ABSTRACT:

Background and aims

Stem cell therapy (SCT) for the treatment of Crohn's disease (CD) is still in its infancy, and whether SCT is associated with improved outcomes is unclear. We performed a meta-analysis to evaluate the efficacy and safety of patients receiving SCT.

Methods

Electronic databases were searched for studies that reported the use of stem cells for the treatment of patients with CD. Raw data from included studies were pooled for effect estimates. Subgroup analyses were performed for exploration of heterogeneity regarding all outcomes.

Results

We analyzed 21 studies comprising 514 patients with active CD. A random-effects meta-analysis of studies of SCT as systemic infusion showed 56% (95% confidence interval (CI) 33-76, n = 150) of patients achieved clinic

SUBMITTER: Qiu Y 

PROVIDER: S-EPMC5460506 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature