RimabotulinumtoxinB in sialorrhea: systematic review of clinical trials.

ABSTRACT:

Objective

The aim of this study was to examine the efficacy, safety and dosing practices of rimabotulinumtoxinB (BoNT-B) for the treatment of patients with sialorrhea based on a systematic review of clinical trials.

Methods

A systematic literature review was performed to identify randomized controlled trials and other comparative clinical studies of BoNT-B for the treatment of sialorrhea published in English between January 1999 and December 2015. Medical literature databases (PubMed, Cochrane Library, and EMBASE) were searched and a total of 41 records were identified. Of these, six primary publications that evaluated BoNT-B for the treatment of sialorrhea met criteria and were included in the final data report.

Synthesis

Total BoNT-B doses ranged from 1500 to 4000 u

SUBMITTER: Dashtipour K 

PROVIDER: S-EPMC5460542 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature