N-acetyltransferase gene polymorphisms & plasma isoniazid concentrations in patients with tuberculosis.

ABSTRACT:

Background & objectives

Variations in the N-acetyltransferase (NAT2) gene among different populations could affect the metabolism and disposition of isoniazid (INH). This study was performed to genotype NAT2 gene polymorphisms in tuberculosis (TB) patients from Chennai, India, and compare plasma INH concentrations among the different genotypes.

Methods

Adult patients with TB treated in the Revised National TB Control Programme (RNTCP) in Chennai, Tamil Nadu, were genotyped for NAT2 gene polymorphism, and two-hour post-dosing INH concentrations were compared between the different genotypes. Plasma INH was determined by high-performance liquid chromatography. Genotyping of the NAT2 gene polymorphism was performed by real-time polymerase chain reaction method.

Results

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SUBMITTER: Hemanth Kumar AK 

PROVIDER: S-EPMC5460557 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature