Effect of caloric restriction on plasma melatonin levels in aged rhesus macaques.

ABSTRACT: In this study, we examined the 24-hour plasma melatonin patterns of young adult (∼11 years of age) and old (∼24 years of age) rhesus macaques, and determined how they would be influenced by 30% caloric restriction (CR). Well-defined 24-hour plasma melatonin rhythms were observed in all the males but only the old animals showed significant attenuation of night-time melatonin levels. Moreover, 4.5 years of CR failed to prevent the age-associated decline in plasma melatonin levels in the old males and caused a significant decrease in the young adult males. Similar plasma melatonin rhythms were also observed in all the females but no age-related decline was detected, and 2 years of CR had no obvious effect on plasma melatonin levels. If anything, there was a trend for the CR to decrease melato

SUBMITTER: Aghazadeh-Sanai N 

PROVIDER: S-EPMC5460625 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature