Mechanisms of Cardiomyocyte Proliferation and Differentiation in Development and Regeneration.

ABSTRACT:

Purpose of review

Congenital heart disease is the most common birth defect and acquired heart disease is the leading cause of death in adults. Understanding the mechanisms that drive cardiomyocyte proliferation and differentiation has the potential to advance the understanding and potentially the treatment of different cardiac pathologies, ranging from myopathies and heart failure to myocardial infarction. This review focuses on studies aimed at elucidating signal transduction pathways and molecular mechanisms that promote proliferation, differentiation, and regeneration of differentiated heart muscle cells, cardiomyocytes.

Recent findings

There is now significant evidence that demonstrates cardiomyocytes continue to proliferate into adulthood. Potential regulators have been

SUBMITTER: Yester JW 

PROVIDER: S-EPMC5460671 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature