Emerging Roles for MicroRNAs in Diabetic Microvascular Disease: Novel Targets for Therapy.

ABSTRACT: Chronic, low-grade systemic inflammation and impaired microvascular function are critical hallmarks in the development of insulin resistance. Accordingly, insulin resistance is a major risk factor for type 2 diabetes and cardiovascular disease. Accumulating studies demonstrate that restoration of impaired function of the diabetic macro- and microvasculature may ameliorate a range of cardiovascular disease states and diabetes-associated complications. In this review, we focus on the emerging role of microRNAs (miRNAs), noncoding RNAs that fine-tune target gene expression and signaling pathways, in insulin-responsive tissues and cell types important for maintaining optimal vascular homeostasis and preventing the sequelae of diabetes-induced end organ injury. We highlight current pathophysiol

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC5460677 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature