Time-Varying Association of Individual BP Components with eGFR in Late-Stage CKD.

ABSTRACT:

Background and objectives

The association of individual BP components with changes in eGFR in patients with late-stage CKD is unknown. The objectives of our study were to examine the associations of systolic BP, diastolic BP, and pulse pressure with continuous temporal changes in eGFR and an eGFR decline ≥30% in late-stage CKD.

Design, setting, participants, & measurements

We performed a retrospective cohort study (2010-2015) of patients with CKD in a multidisciplinary CKD clinic with an eGFR≤30. The associations of repeat measures of BP (systolic BP, diastolic BP, and pulse pressure) with eGFR were examined using general linear mixed models. The associations of BP components and eGFR decline ≥30% were examined with time-varying Cox models.

Results

In total, 1203 pati

SUBMITTER: Sood MM 

PROVIDER: S-EPMC5460704 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature