FGF23 Is Not Associated With Age-Related Changes in Phosphate, but Enhances Renal Calcium Reabsorption in Girls.

ABSTRACT:

Context

Fibroblast growth factor (FGF)23 is a critical determinant of phosphate homeostasis. The role of FGF23, however, in regulating physiologic changes in serum phosphate and renal phosphate handling across childhood is not well described. In addition, animal models have suggested a role for FGF23 in regulating renal calcium excretion.

Objective

To assess changes in FGF23 concentrations across childhood in relation to changes in mineral ions and hormones of mineral ion homeostasis.

Design

This was a cross-sectional study.

Setting

The study was conducted at a Clinical Research Center at a tertiary care hospital.

Patients or other participants

Ninety healthy girls ages 9 to 18 years were recruited from the surrounding community.

Main outcome measures

SUBMITTER: Mitchell DM 

PROVIDER: S-EPMC5460726 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature