Effects of Cholecalciferol vs Calcifediol on Total and Free 25-Hydroxyvitamin D and Parathyroid Hormone.

ABSTRACT:

Context

Vitamin D deficiency disproportionately affects nonwhite individuals. Controversy persists over how to best restore low 25D levels, and how to best define vitamin D status [total (protein bound plus free) vs free 25D].

Objective

To assess the effects of vitamin D3 (cholecalciferol, or D3) vs 25-hydroxyvitamin D3 (calcifediol, or 25D3) on total and free 25D in a multiethnic cohort of adults, and whether change in parathyroid hormone (PTH) is more strongly associated with total vs free 25D.

Design

Sixteen-week randomized controlled trial. Biochemistries at 0, 4, 8, and 16 weeks.

Setting

Academic medical center.

Participants

Thirty-five adults ≥18 years of age with 25D levels <20 ng/mL.

Intervention

Sixty micrograms (2400 IU)/d of D3 or 20 μg

SUBMITTER: Shieh A 

PROVIDER: S-EPMC5460735 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature