Preoperative serum cystatin-C as a potential biomarker for prognosis of renal cell carcinoma.

ABSTRACT:

Purpose

The prognostic value of serum cystatin-C (Cys-C) in renal cell carcinoma (RCC) remains unknown. The purpose of this study is to explore the prognostic value of Cys-C for RCC patients.

Patients and methods

The levels of preoperative Cys-C, creatinine (CRE) and estimated glomerular filtration rate (e-GFR) were retrospectively collected in 325 RCC patients undergoing surgery. The cutoff values of Cys-C, CRE and e-GFR were determined by the standardized Cutoff Finder algorithm. The receiver operating characteristic (ROC) curve and pairwise comparison were performed to compare the three variables. Univariate and multivariate Cox regression analyses were performed to investigate the prognostic value of serum Cys-C in RCC.

Results

Based on the analysis of Cutoff Find

SUBMITTER: Guo S 

PROVIDER: S-EPMC5460820 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature