Hepatic Insulin Resistance and Altered Gluconeogenic Pathway in Premature Baboons.

ABSTRACT: Premature infants have altered glucose regulation early in life and increased risk for diabetes in adulthood. Although prematurity leads to an increased risk of diabetes and metabolic syndrome in adult life, the role of hepatic glucose regulation and adaptation to an early extrauterine environment in preterm infants remain unknown. The purpose of this study was to investigate developmental differences in glucose metabolism, hepatic protein content, and gene expression of key insulin-signaling/gluconeogenic molecules. Fetal baboons were delivered at 67%, 75%, and term gestational age and euthanized at birth. Neonatal baboons were delivered prematurely (67% gestation), survived for two weeks, and compared with similar postnatal term animals and underwent serial hyperinsulinemic-euglycemic cl

SUBMITTER: McGill-Vargas L 

PROVIDER: S-EPMC5460827 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature