Long-term tremor therapy for Parkinson and essential tremor with sensor-guided botulinum toxin type A injections.

ABSTRACT:

Objective

Current pharmacological agents used to treat Parkinson disease (PD) tremor and essential tremor (ET) provide suboptimal benefit and are commonly associated with significant adverse effects. Botulinum toxin type A (BoNT-A) has been shown to be effective for wrist tremor though functionally bothersome muscle weakness frequently occurs. This is the longest study to date demonstrating that BoNT-A therapy coupled with kinematic guidance can provide efficacious outcomes for upper limb tremor with minimized unwanted weakness.

Methods

A total of 28 PD and 24 ET participants with bothersome, disabling tremor, received six serial BoNT-A treatments every 16 weeks starting at week 0 with a follow-up visit 6 weeks following a treatment, totaling 96 weeks. Clinical scales, inclu

SUBMITTER: Samotus O 

PROVIDER: S-EPMC5460844 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature