Tandem duplications lead to novel expression patterns through exon shuffling in Drosophila yakuba.

ABSTRACT: One common hypothesis to explain the impacts of tandem duplications is that whole gene duplications commonly produce additive changes in gene expression due to copy number changes. Here, we use genome wide RNA-seq data from a population sample of Drosophila yakuba to test this 'gene dosage' hypothesis. We observe little evidence of expression changes in response to whole transcript duplication capturing 5' and 3' UTRs. Among whole gene duplications, we observe evidence that dosage sharing across copies is likely to be common. The lack of expression changes after whole gene duplication suggests that the majority of genes are subject to tight regulatory control and therefore not sensitive to changes in gene copy number. Rather, we observe changes in expression level due to both shuffling of

SUBMITTER: Rogers RL 

PROVIDER: S-EPMC5460883 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature