WMel limits zika and chikungunya virus infection in a Singapore Wolbachia-introgressed Ae. aegypti strain, wMel-Sg.

ABSTRACT: BACKGROUND:Zika (ZIKV) and Chikungunya (CHIKV) viruses are emerging Aedes-borne viruses that are spreading outside their known geographic range and causing wide-scale epidemics. It has been reported that these viruses can be transmitted efficiently by Ae. aegypti. Recent studies have shown that Ae. aegypti when transinfected with certain Wolbachia strains shows a reduced replication and dissemination of dengue (DENV), Chikungunya (CHIKV), and Yellow Fever (YFV) viruses. The aim of this study was to determine whether the wMel strain of Wolbachia introgressed onto a Singapore Ae. aegypti genetic background was able to limit ZIKV and CHIKV infection in the mosquito. METHODOLOGY/PRINCIPAL FINDINGS:Five to seven-day old mosquitoes either infected or uninfected with wMel Wolbachia were orally in

SUBMITTER: Tan CH 

PROVIDER: S-EPMC5460886 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature