Multi-scale computational study of the mechanical regulation of cell mitotic rounding in epithelia.

ABSTRACT: Mitotic rounding during cell division is critical for preventing daughter cells from inheriting an abnormal number of chromosomes, a condition that occurs frequently in cancer cells. Cells must significantly expand their apical area and transition from a polygonal to circular apical shape to achieve robust mitotic rounding in epithelial tissues, which is where most cancers initiate. However, how cells mechanically regulate robust mitotic rounding within packed tissues is unknown. Here, we analyze mitotic rounding using a newly developed multi-scale subcellular element computational model that is calibrated using experimental data. Novel biologically relevant features of the model include separate representations of the sub-cellular components including the apical membrane and cytoplasm of

SUBMITTER: Nematbakhsh A 

PROVIDER: S-EPMC5460904 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature