Quantifying cortical development in typically developing toddlers and young children, 1-6 years of age.

ABSTRACT: Cortical maturation, including age-related changes in thickness, volume, surface area, and folding (gyrification), play a central role in developing brain function and plasticity. Further, abnormal cortical maturation is a suspected substrate in various behavioral, intellectual, and psychiatric disorders. However, in order to characterize the altered development associated with these disorders, appreciation of the normative patterns of cortical development in neurotypical children between 1 and 6 years of age, a period of peak brain development during which many behavioral and developmental disorders emerge, is necessary. To this end, we examined measures of cortical thickness, surface area, mean curvature, and gray matter volume across 34 bilateral regions in a cohort of 140 healthy child

SUBMITTER: Remer J 

PROVIDER: S-EPMC5460988 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature